Significant changes are noticed in hair morphology in those people who are suffering from androgenetic alopecia. The affected hair follicles differ from normal hair growth and that matters a lot in any treatment for hair loss.
Acute And Active Lesions
There are acute and active lesions (any visible abnormal structural change in a bodily part) where the hair follicles have greatest divergence from the normal growth pattern. These changes are the overt display of the features of the primary disease pathology.
Changes In The Hair Bulbs Of Anagen Hair Follicles
In androgenetic alopecia, there are regressive changes in the hair bulbs of anagen hair follicles.
The tissue injury is not cell type specific. But pre-cortical keratinocytes and hair bulb melanocytes are affected alogn with the main target of androgenetic alopecia - the dermal papilla cells.
Abnormal Melanogenesis
Abnormal melanogenesis is a common feature in the hair morphology of those suffering from androgenetic alopecia. It might be the reason for some of the associated pigmentary anomalies seen clinically in acute hair loss.
Premature Involution Of Suboptimal Anagen Hair Follicles
Tissue damage might explain why there is premature involution of suboptimal anagen hair follicles into an early resting phase in androgenetic alopecia.
