Enzymes Are A Decisive Factor In Androgenetic Alopecia

Male Pattern Baldness
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Enzymes - Decisive Factors in Hair Growth

Enzymes are one of the decisive factors as far as hair growth is concerned. Their functioning is a key factor in the hair growth process. And abnormal levels of enzymes can expose you to the unpleasent condition of Androgenetic Alopecia.

Their role in the hair growth process
Enzymes are proteins that play the role of a catalyast in chemical reactions. Besides governing various bodily functions, enzymes also control hair growth.

Differences in the levels of enzymes and hormones
Differences in the levels of enzymes and hormones are likely to cause imbalances in the biological process of hair growth. And that results in various problems.
The growth of beard, body hair and armpit hair in males are governed by the male sex hormone, testosterone. In women, the female sex hormone, estrogen prevents hair growth on the chin and encourages its growth on the head. A drop in estrogen level will cause women to develop signs of Hair Loss or Baldness. Rapid hair growth and stunted hair growth are both the outcomes of hormonal imbalances.
The Proteolytic Enzyme Bromelain
It breaks down protein and it is directly related to hair growth. Bromelain supplements form an integral part of many natural hair care products.

Role played by some enzymes in hair growth
  • Phenol-oxydase - It is partly responsible for the growth of melanocyte cells. These cells produce melanin, the pigment that determines the hair color.
  • Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) - They stimulate growth of cells in the hair follicle and maintain the dermal papilla cells. The latter is the main center of hair growth regulation and growth promotIon.
  • Stromelysin - It acts on the dermal papilla cells and stimulates their activity.
  • Insulin-like growth factor I (IGF - I) - It causes acceleration of growth of hair and hair follicles. Its actions are modulated by proteins produced in dermal papilla cells binding IGF. Body hair in patients with hyperinsulinism reportedly has a male distribution pattern.
  • Androgens - Androgens have diverse effects on human hair varying in different parts of the body. The hair growth effects have diverse variations - essentialy nonexistent, weak, moderate, and strong.
  • Effects on dermal papilla cells - Dermal papilla cells are mostly affected by 5- a-dihydrotestosterone. It is synthesized under the catalytic action of the enzyme 5- a-reductase.
The growth of androgen-dependent hairs are affected in various ways by -